ea0011p240 | Cytokines and growth factors | ECE2006
Hu Y
, Kim S
, Cadman S
, Guimond S
, Turnbull J
, Bouloux P
Introduction: Autosomal dominant Kallmanns syndrome (AKS) results from mutations within the fibroblast growth factor receptor 1 (FGFR1: KAL-2). The FGFR family of tyrosine kinases are involved in a multitude of biological processes from embryogenesis to adult homeostasis. The crystal structure of FGF-FGFR-heparan sulphate (HS) ternary complex has provided a basis for understanding the way in which FGF, FGFR and HS cooperate to assist FGFR dimerization. Anosmin-1, KAL-1 g...